Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

Outer membrane vesicles (OMVs) are proteoliposomes blebbed from the surface of Gram-negative bacteria. Chronic periodontitis is associated with an increase in subgingival plaque of Gram-negative bacteria, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. In this study, we inve...

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Bibliographic Details
Main Authors: Jessica D. Cecil, Neil M. O’Brien-Simpson, Jason C. Lenzo, James A. Holden, William Singleton, Alexis Perez-Gonzalez, Ashley Mansell, Eric C. Reynolds
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
outer membrane vesicles
macrophages
inflammasomes
Porphyromonas gingivalis
Treponema denticola
Tannerella forsythia
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01017/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01017/full

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