Cell Death Mechanisms Induced by CLytA-DAAO Chimeric Enzyme in Human Tumor Cell Lines

Cell Death Mechanisms Induced by CLytA-DAAO Chimeric Enzyme in Human Tumor Cell Lines

The combination of the choline binding domain of the amidase N-acetylmuramoyl-L-alanine (CLytA)-D-amino acid oxidase (DAAO) (CLytA-DAAO) and D-Alanine induces cell death in several pancreatic and colorectal carcinoma and glioblastoma cell lines. In glioblastoma cell lines, CLytA-DAAO-induced cell de...

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Bibliographic Details
Main Authors: María Fuentes-Baile, Pilar García-Morales, Elizabeth Pérez-Valenciano, María P. Ventero, Jesús M. Sanz, Camino de Juan Romero, Víctor M. Barberá, Cristina Alenda, Miguel Saceda
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
cancer therapy
reactive oxygen species
oxidative damage
mitochondrial membrane potential
calcium mobilization
PARP-1
Online Access:https://www.mdpi.com/1422-0067/21/22/8522

Internet

https://www.mdpi.com/1422-0067/21/22/8522

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