Allele frequencies of variants in ultra conserved elements identify selective pressure on transcription factor binding.

Allele frequencies of variants in ultra conserved elements identify selective pressure on transcription factor binding.

Ultra-conserved genes or elements (UCGs/UCEs) in the human genome are extreme examples of conservation. We characterized natural variations in 2884 UCEs and UCGs in two distinct populations; Singaporean Chinese (n = 280) and Italian (n = 501) by using a pooled sample, targeted capture, sequencing ap...

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Bibliographic Details
Main Authors: Toomas Silla, Katrin Kepp, E Shyong Tai, Liang Goh, Sonia Davila, Tina Catela Ivkovic, George A Calin, P Mathijs Voorhoeve
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4219694?pdf=render

Internet

http://europepmc.org/articles/PMC4219694?pdf=render

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