High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice

High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice

In the large GWAS studies, <i>NEGR1</i> gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis, by using both male and female &...

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Bibliographic Details
Main Authors: Maria Kaare, Kaie Mikheim, Kersti Lilleväli, Kalle Kilk, Toomas Jagomäe, Este Leidmaa, Maria Piirsalu, Rando Porosk, Katyayani Singh, Riin Reimets, Egon Taalberg, Michael K. E. Schäfer, Mario Plaas, Eero Vasar, Mari-Anne Philips
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomedicines
Subjects:
<i>Negr1</i>
obesity
metabolic disease
metabolomics
glucose intolerance
genetic models
Online Access:https://www.mdpi.com/2227-9059/9/9/1148

Internet

https://www.mdpi.com/2227-9059/9/9/1148

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