Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents

Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents

Abstract Pyrimidine nucleus is a significant pharmacophore that exhibited excellent pharmacological activities. A series of pyrimidine scaffolds was synthesized and its chemical structures were confirmed by physicochemical and spectral analysis. The synthesized compounds were evaluated for their ant...

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Bibliographic Details
Main Authors: Sanjiv Kumar, Archana Kaushik, Balasubramanian Narasimhan, Syed Adnan Ali Shah, Siong Meng Lim, Kalavathy Ramasamy, Vasudevan Mani
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Chemistry
Subjects:
Pyrimidine analogues
Antibacterial activity
Anticancer activity
Docking study
Online Access:http://link.springer.com/article/10.1186/s13065-019-0601-z

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http://link.springer.com/article/10.1186/s13065-019-0601-z

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