Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR Signaling

Skeletal muscle mass is a result of the balance between protein breakdown and protein synthesis. It has been shown that multiple conditions of muscle atrophy are characterized by the common regulation of a specific set of genes, termed atrogenes. It is not known whether various models of muscle hype...

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Bibliographic Details
Main Authors: Marcelo G. Pereira, Kenneth A. Dyar, Leonardo Nogara, Francesca Solagna, Manuela Marabita, Martina Baraldo, Francesco Chemello, Elena Germinario, Vanina Romanello, Hendrik Nolte, Bert Blaauw
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00968/full