PPARγ SIGNALING IS REQUIRED FOR MEDIATING EETS PROTECTIVE EFFECTS IN NEONATAL CARDIOMYOCYTES EXPOSED TO LPS

PPARγ SIGNALING IS REQUIRED FOR MEDIATING EETS PROTECTIVE EFFECTS IN NEONATAL CARDIOMYOCYTES EXPOSED TO LPS

Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Epoxyeicosatrienoic acids (EETs) are biologically active metabolites of arachidonic acids capable of activating protective cellular pathway...

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Bibliographic Details
Main Authors: Victor eSamokhvalov, Jelle eVriend, Kristi L Jamieson, Maria eAkhnokh, Rajkumar eManne, John R Falck, John M. Seubert
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Pharmacology
Subjects:
Inflammation
PPARγ
LPS
cardiac cells
epoxyeicosatrienoic acid
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00242/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00242/full

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