PPARγ SIGNALING IS REQUIRED FOR MEDIATING EETS PROTECTIVE EFFECTS IN NEONATAL CARDIOMYOCYTES EXPOSED TO LPS
Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Epoxyeicosatrienoic acids (EETs) are biologically active metabolites of arachidonic acids capable of activating protective cellular pathway...
Main Authors: | Victor eSamokhvalov, Jelle eVriend, Kristi L Jamieson, Maria eAkhnokh, Rajkumar eManne, John R Falck, John M. Seubert |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-11-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00242/full |
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