Wnt/β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway

Wnt/β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway

Aim: The Wnt/β-catenin signaling pathway plays an important role in ischemia-reperfusion(I/R) injury, and the transforming growth factor(TGF)-β/Smad signaling pathway participates in the neuroprotection effect induced by isoflurane(ISO) postconditioning. In this study, we aimed to explore the role o...

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Bibliographic Details
Main Authors: Guixing Zhang, Mingyue Ge, Ziwei Han, Sheng Wang, Jiangwen Yin, Li Peng, Feng Xu, Qingtong Zhang, Zhigang Dai, Liping Xie, Yan Li, Junqiang Si, Ketao Ma
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Isoflurane
Postconditioning
Wnt/β-catenin
Transforming growth factor beta (TGF- β)
Cerebral ischemia–reperfusion injury
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218362930

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http://www.sciencedirect.com/science/article/pii/S0753332218362930

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