The Novel Oral BET-CBP/p300 Dual Inhibitor NEO2734 Is Highly Effective in Eradicating Acute Myeloid Leukemia Blasts and Stem/Progenitor Cells

The Novel Oral BET-CBP/p300 Dual Inhibitor NEO2734 Is Highly Effective in Eradicating Acute Myeloid Leukemia Blasts and Stem/Progenitor Cells

Acute myeloid leukemia (AML) is a disease characterized by transcriptional dysregulation that results in a block in differentiation and aberrant self-renewal. Inhibitors directed to epigenetic modifiers, aiming at transcriptional reprogramming of AML cells, are currently in clinical trials for AML p...

Full description

Bibliographic Details
Main Authors: Noortje van Gils, Tania Martiañez Canales, Eline Vermue, Arjo Rutten, Fedor Denkers, Tiem van der Deure, Gert J. Ossenkoppele, Francis Giles, Linda Smit
Format: Article
Language:English
Published: Wolters Kluwer 2021-08-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000610

Internet

http://journals.lww.com/10.1097/HS9.0000000000000610

Similar Items