Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model

Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model

HSP70 is one of the main molecular chaperones involved in the cellular stress response. Besides its chaperone action, HSP70 also modulates the immune response. Increased susceptibility to toxic insults in intra- and extracellular environments has been associated with insufficient amounts of inducibl...

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Bibliographic Details
Main Authors: Camila Tiefensee Ribeiro, Daniel Oppermann Peixoto, Lucas Santos, Carolina Saibro-Girardi, Pedro Ozorio Brum, Flávio Gabriel Carazza-Kessler, Nauana Somensi, Luiza Marques Prates Behrens, Reykla Ramon Bittencourt, Laíssa Santos Soares, Alexandre Kleber Silveira, Jade de Oliveira, José Cláudio Fonseca Moreira, Juciano Gasparotto, Daniel Pens Gelain
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Exogenous HSP70
Intranasal treatment
6-OHDA
Neuroprotection
Neuroinflammation
Neurodegenerative diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354621000569

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http://www.sciencedirect.com/science/article/pii/S2666354621000569

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