Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help...

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Bibliographic Details
Main Authors: Joel Kidman, Nicola Principe, Mark Watson, Timo Lassmann, Robert A. Holt, Anna K. Nowak, Willem Joost Lesterhuis, Richard A. Lake, Jonathan Chee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
checkpoint immunotherapy
tumor immunology
T cell receptor
immunogenomics
dynamic analysis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.587014/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.587014/full

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