Challenges in Optimizing a Prostate Carcinoma Binding Peptide, Identified through the Phage Display Technology

Challenges in Optimizing a Prostate Carcinoma Binding Peptide, Identified through the Phage Display Technology

The transfer of peptides identified through the phage display technology to clinical applications is difficult. Major drawbacks are the metabolic degradation and label instability. The aim of our work is the optimization of DUP-1, a peptide which was identified by phage display to specifically targe...

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Bibliographic Details
Main Authors: Jürgen Debus, Uwe Haberkorn, Walter Mier, Annabell Marr, Shoaib Rana, Frederic Zoller, Annette Altmann, Vasileios Askoxylakis, Annette Markert, Sabine Zitzmann-Kolbe
Format: Article
Language:English
Published: MDPI AG 2011-02-01
Series:Molecules
Subjects:
phage display
peptide
prostate carcinoma
radiolabeling
affinity
Online Access:http://www.mdpi.com/1420-3049/16/2/1559/

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http://www.mdpi.com/1420-3049/16/2/1559/

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