An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

High levels of plasma apolipoprotein B-100 (apoB-100), the principal apolipoprotein of LDL, are associated with cardiovascular disease. We hypothesized that suppression of apoB-100 mRNA by an antisense oligonucleotide (ASO) would reduce LDL cholesterol (LDL-C). Because most of the plasma apoB is mad...

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Bibliographic Details
Main Authors: Rosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Charles P. Whipple, Seonjoon Koo, Ranjan J. Perera
Format: Article
Language:English
Published: Elsevier 2005-05-01
Series:Journal of Lipid Research
Subjects:
lipid metabolism
hypercholesterolemia
apoB-100
apoB-48
fat malabsorption
MTP inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520339705

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http://www.sciencedirect.com/science/article/pii/S0022227520339705

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