Does the Chemotherapy Backbone Impact on the Efficacy of Targeted Agents in Metastatic Colorectal Cancer? A Systematic Review and Meta-Analysis of the Literature.

Does the Chemotherapy Backbone Impact on the Efficacy of Targeted Agents in Metastatic Colorectal Cancer? A Systematic Review and Meta-Analysis of the Literature.

The EGFR inhibitors (EGFR-I) cetuximab and panitumumab and the angiogenesis inhibitors (AIs) bevacizumab and aflibercept have demonstrated varying efficacy in mCRC.To document the overall impact of specific chemotherapy regimens on the efficacy of targeted agents in treating patients with mCRC.MEDLI...

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Bibliographic Details
Main Authors: David L Chan, Nick Pavlakis, Jeremy Shapiro, Timothy J Price, Christos S Karapetis, Niall C Tebbutt, Eva Segelov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4537274?pdf=render

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http://europepmc.org/articles/PMC4537274?pdf=render

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