Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets

A longitudinal analysis of SARS-CoV-2 infection in humans is challenging. Here the authors show a single cell RNA-sequencing analysis of BAL fluid cells from ferrets and characterise the time dependent recruitment of macrophage subsets to the lungs in response to SARS-CoV-2 infection.

Bibliographic Details
Main Authors: Jeong Seok Lee, June-Young Koh, Kijong Yi, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Se-Mi Kim, Sung Ho Park, Young Seok Ju, Young Ki Choi, Su-Hyung Park
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24807-0