The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice

Increased levels of heat shock protein 90 (HSP90) have been recently implicated in the pathogenesis of pulmonary fibrosis and the use of HSP90 inhibitors constitutes a potential therapeutic approach. Similarly, acute exposure to nitrogen mustard (NM) is related to the development of chronic lung inj...

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Bibliographic Details
Main Authors: Pavel Solopov, Ruben M. L. Colunga Biancatelli, Margarita Marinova, Christiana Dimitropoulou, John D. Catravas
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
ERK
Online Access:https://www.mdpi.com/1422-0067/21/13/4740