TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation

The hyaluronan receptor CD44 can undergo proteolytic cleavage in two steps, leading to the release of its intracellular domain; this domain is translocated to the nucleus, where it affects the transcription of target genes. We report that CD44 cleavage in A549 lung cancer cells and other cells is pr...

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Bibliographic Details
Main Authors: Constantinos Kolliopoulos, Athanasios Chatzopoulos, Spyros S. Skandalis, Carl-Henrik Heldin, Paraskevi Heldin
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/13/5/1021