Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations

Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations

G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with α subunits of distinct G protein families, they regulate cellular responses. The histamine H<sub>2</sub...

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Bibliographic Details
Main Authors: Carina Höring, Marcus Conrad, Christian A. Söldner, Jinan Wang, Heinrich Sticht, Andrea Strasser, Yinglong Miao
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
GPCR–G protein coupling profiles
Gaussian accelerated molecular dynamics (GaMD)
split-luciferase complementation assay
histamine signaling
histamine H<sub>2</sub> receptor
histamine H<sub>4</sub> receptor
Online Access:https://www.mdpi.com/1422-0067/22/18/10047

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https://www.mdpi.com/1422-0067/22/18/10047

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