ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity

ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity

Summary: Numerous mammalian cells contain abundant Zn2+ in their secretory granules, yet available Zn2+ sensors lack the desired specificity and sensitivity for imaging granular Zn2+. We developed a fluorescent zinc granule indicator, ZIGIR, that possesses numerous desired properties for live cell i...

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Bibliographic Details
Main Authors: Ebrahim H. Ghazvini Zadeh, ZhiJiang Huang, Jing Xia, Daliang Li, Howard W. Davidson, Wen-hong Li
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
Zinc sensor
zinc imaging
ZIGIR
beta cell
delta cell
alpha cell heterogeneity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308858

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http://www.sciencedirect.com/science/article/pii/S2211124720308858

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