Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis

Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis

Background/Aims: Three rare MAPK7 variants that predispose individuals to adolescent idiopathic scoliosis have previously been identified. However, the mechanism underlying the effects of the mutations remain unknown. Methods: Human mesenchymal stem cells (hMSCs) were isolated from both patients and...

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Bibliographic Details
Main Authors: Taifeng Zhou, Chong Chen, Caixia Xu, Hang Zhou, Bo Gao, Deying Su, Zhiheng Liao, Yongyong Li, Shulan Yang, Peiqiang Su
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Mapk7
Idiopathic scoliosis
Zebrafish
HMSC
Osteogenesis
RPS6KA3
Online Access:https://www.karger.com/Article/FullText/491956

Internet

https://www.karger.com/Article/FullText/491956

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