5-Methoxyl Aesculetin Abrogates Lipopolysaccharide-Induced Inflammation by Suppressing MAPK and AP-1 Pathways in RAW 264.7 Cells

5-Methoxyl Aesculetin Abrogates Lipopolysaccharide-Induced Inflammation by Suppressing MAPK and AP-1 Pathways in RAW 264.7 Cells

For the first time, a pale amorphous coumarin derivative, 5-methoxyl aesculetin (MOA), was isolated from the dried bark of Fraxinus rhynchophylla Hance (Oleaceae). MOA modulates cytokine expression in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages, but the precise mechanisms are still not fu...

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Bibliographic Details
Main Authors: Lei Wu, Xueqin Li, Haifeng Wu, Wei Long, Xiaojian Jiang, Ting Shen, Qian Qiang, Chuanling Si, Xinfeng Wang, Yunyao Jiang, Weicheng Hu
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Molecular Sciences
Subjects:
5-methoxyl aesculetin
activator protein-1
mitogen-activated protein kinases
inflammation
Online Access:http://www.mdpi.com/1422-0067/17/3/315

Internet

http://www.mdpi.com/1422-0067/17/3/315

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