Decreased frequencies of circulating follicular helper T cell counterparts and plasmablasts in ankylosing spondylitis patients Naïve for TNF blockers.

Decreased frequencies of circulating follicular helper T cell counterparts and plasmablasts in ankylosing spondylitis patients Naïve for TNF blockers.

Follicular helper T cells (Tfh), localized in lymphoid organs, promote B cell differentiation and function. Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of Tfh. Three subpopulations of circulating CD4+CXCR5+ cells have been described: CXCR3+CCR6- (Tfh-Th1), CXCR3-CCR6+...

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Bibliographic Details
Main Authors: María-Belén Bautista-Caro, Irene Arroyo-Villa, Concepción Castillo-Gallego, Eugenio de Miguel, Diana Peiteado, Chamaida Plasencia-Rodríguez, Alejandro Villalba, Paloma Sánchez-Mateos, Amaya Puig-Kröger, Emilio Martín-Mola, María-Eugenia Miranda-Carús
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4159293?pdf=render

Internet

http://europepmc.org/articles/PMC4159293?pdf=render

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