Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases

Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases

Abstract Background Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of developing metastases in the brain. Despite gains with systemic control of Her2+ disease using molecular therapies, brain metastases remain recalcitrant t...

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Bibliographic Details
Main Authors: Cecilia Choy, Khairul I. Ansari, Josh Neman, Sarah Hsu, Matthew J. Duenas, Hubert Li, Nagarajan Vaidehi, Rahul Jandial
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Breast Cancer Research
Subjects:
Breast cancer brain metastasis
Epidermal growth factor receptor 2 (Her2+)
Tropomyosin-related kinase B (TrkB)
Brain-derived neurotrophic factor (BDNF)
Neurotrophins
Neural microenvironment
Online Access:http://link.springer.com/article/10.1186/s13058-017-0844-3

Internet

http://link.springer.com/article/10.1186/s13058-017-0844-3

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