Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling

Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling

Objective: The protein microfibril-associated glycoprotein (MAGP)-1 constitutes a crucial extracellular matrix protein. We aimed to determine its impact on visceral adipose tissue (VAT) remodelling during obesity-associated colon cancer (CC). Methods: Samples obtained from 79 subjects (29 normoponde...

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Bibliographic Details
Main Authors: Iranzu Gómez de Segura, Patricia Ahechu, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Sara Becerril, Xabier Unamuno, Amaia Mentxaka, Jorge Baixauli, Víctor Valentí, Rafael Moncada, Camilo Silva, Gema Frühbeck, Victoria Catalán
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
obesity
colon cancer
adipose tissue
inflammation
extracellular matrix remodelling
MAGP-1
Online Access:https://www.mdpi.com/1422-0067/22/16/8485

Internet

https://www.mdpi.com/1422-0067/22/16/8485

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