Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions.

Bibliographic Details
Main Authors: Huifen Cao, Lorena Salazar-García, Fan Gao, Thor Wahlestedt, Chun-Lin Wu, Xueer Han, Ye Cai, Dongyang Xu, Fang Wang, Lu Tang, Natalie Ricciardi, DingDing Cai, Huifang Wang, Mario P. S. Chin, James A. Timmons, Claes Wahlestedt, Philipp Kapranov
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13602-7

Internet

https://doi.org/10.1038/s41467-019-13602-7

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