Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions.
Bibliographic Details
| Main Authors: |
Huifen Cao,
Lorena Salazar-García,
Fan Gao,
Thor Wahlestedt,
Chun-Lin Wu,
Xueer Han,
Ye Cai,
Dongyang Xu,
Fang Wang,
Lu Tang,
Natalie Ricciardi,
DingDing Cai,
Huifang Wang,
Mario P. S. Chin,
James A. Timmons,
Claes Wahlestedt,
Philipp Kapranov |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-13602-7
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