Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in <i>Leucine-Rich Glioma-Inactivated 1</i> (<i>Lgi1</i>) Mutant Rats

Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in <i>Leucine-Rich Glioma-Inactivated 1</i> (<i>Lgi1</i>) Mutant Rats

The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy. Here, we analyzed the Kir4.1 expressional changes in <i>Leucine-Rich Glioma-Inactivated...

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Bibliographic Details
Main Authors: Masato Kinboshi, Saki Shimizu, Tomoji Mashimo, Tadao Serikawa, Hidefumi Ito, Akio Ikeda, Ryosuke Takahashi, Yukihiro Ohno
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
astrocytes
epilepsy
Kir4.1 channels
Lgi1
ADLTE
antiepileptics
valproic acid
Online Access:https://www.mdpi.com/1422-0067/20/5/1013

Internet

https://www.mdpi.com/1422-0067/20/5/1013

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