Endogenous Carbon Monoxide Signaling Modulates Mitochondrial Function and Intracellular Glucose Utilization: Impact of the Heme Oxygenase Substrate Hemin

Endogenous Carbon Monoxide Signaling Modulates Mitochondrial Function and Intracellular Glucose Utilization: Impact of the Heme Oxygenase Substrate Hemin

Stress-inducible heme oxygenase-1 (HO-1) catalyzes the oxidative cleavage of heme yielding biliverdin, ferrous iron, and carbon monoxide (CO). Heme oxygenase activity has been attributed to antioxidant defense via the redox cycling system of biliverdin and bilirubin. There is increasing evidence tha...

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Bibliographic Details
Main Authors: David Stucki, Julia Steinhausen, Philipp Westhoff, Heide Krahl, Dominik Brilhaus, Annika Massenberg, Andreas P. M. Weber, Andreas S. Reichert, Peter Brenneisen, Wilhelm Stahl
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antioxidants
Subjects:
heme
heme oxygenase
substrate
respiratory chain
metabolism
Online Access:https://www.mdpi.com/2076-3921/9/8/652

Internet

https://www.mdpi.com/2076-3921/9/8/652

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