proBDNF is modified by advanced glycation end products in Alzheimer’s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing

proBDNF is modified by advanced glycation end products in Alzheimer’s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing

Abstract Alzheimer disease (AD) is a complex pathology related to multiple causes including oxidative stress. Brain-derived neurotrophic factor (BDNF) is a neutrotrophic factor essential for the survival and differentiation of neurons and is considered a key target in the pathophysiology of various...

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Bibliographic Details
Main Authors: Catherine Fleitas, Gerard Piñol-Ripoll, Pau Marfull, Daniel Rocandio, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espinet
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Molecular Brain
Subjects:
Alzheimer’s disease
Biomarkers
BDNF
p75
proBDNF
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s13041-018-0411-6

Internet

http://link.springer.com/article/10.1186/s13041-018-0411-6

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