Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition

Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition

Abstract Background Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer propagation. It can be orchestrated by the activation of multiple signaling pathways, which have been found to be highly coordinated with many epigenetic regulators. Although the mechanism of EMT has been s...

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Bibliographic Details
Main Authors: Congcong Lu, Simone Sidoli, Katarzyna Kulej, Karen Ross, Cathy H. Wu, Benjamin A. Garcia
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Epigenetics & Chromatin
Subjects:
Epithelial to mesenchymal transition
Time-resolved quantitative (phospho)proteomics
Comprehensive profiling of histone modifications
Erk signaling
Histone H3 lysine 27 trimethylation
Combinatorial inhibition targeting signaling pathway and epigenetic regulator
Online Access:http://link.springer.com/article/10.1186/s13072-019-0256-y

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http://link.springer.com/article/10.1186/s13072-019-0256-y

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