A novel anticancer therapy that simultaneously targets aberrant p53 and Notch activities in tumors.

A novel anticancer therapy that simultaneously targets aberrant p53 and Notch activities in tumors.

Notch signaling pathway plays an important role in tumorigenesis by maintaining the activity of self-renewal of cancer stem cells, and therefore, it is hypothesized that interference of Notch signaling may inhibit tumor formation and progression. H101 is a recombinant oncolytic adenovirus that is cy...

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Bibliographic Details
Main Authors: Yuting Yao, Li Wang, He Zhang, Haibo Wang, Xiaoping Zhao, Yidan Zhang, Leilei Zhang, Xianqun Fan, Guanxiang Qian, Ji-Fan Hu, Shengfang Ge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3468572?pdf=render

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http://europepmc.org/articles/PMC3468572?pdf=render

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