Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis

Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis

Pericardial tuberculosis (TB) is associated with high therapy failure and high mortality rates. Antibiotics have to penetrate to site of infection at sufficient non-protein bound concentrations, and then enter bacteria to inhibit intracellular biochemical processes. The antibiotic concentrations ach...

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Bibliographic Details
Main Authors: Justin Shenje, F. Ifeoma Adimora-Nweke, Ian L. Ross, Mpiko Ntsekhe, Lubbe Wiesner, Armin Deffur, Helen M. McIlleron, Jotam Pasipanodya, Tawanda Gumbo, Bongani M. Mayosi
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:EBioMedicine
Subjects:
Rifampicin
Ethambutol
Pyrazinamide
Drug penetration
Pericardium
Protein binding
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301420

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http://www.sciencedirect.com/science/article/pii/S2352396415301420

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