PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF.

PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF.

During organogenesis, PAX6 is required for establishment of various progenitor subtypes within the central nervous system, eye and pancreas. PAX6 expression is maintained in a variety of cell types within each organ, although its role in each lineage and how it acquires cell-specific activity remain...

Full description

Bibliographic Details
Main Authors: Shaul Raviv, Kapil Bharti, Sigal Rencus-Lazar, Yamit Cohen-Tayar, Rachel Schyr, Naveh Evantal, Eran Meshorer, Alona Zilberberg, Maria Idelson, Benjamin Reubinoff, Rhonda Grebe, Rina Rosin-Arbesfeld, James Lauderdale, Gerard Lutty, Heinz Arnheiter, Ruth Ashery-Padan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4038462?pdf=render

Internet

http://europepmc.org/articles/PMC4038462?pdf=render

Similar Items