Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus.

Daptomycin remains one of our last-line anti-staphylococcal agents. This study aims to characterize the genetic evolution to daptomycin resistance in S. aureus.Whole genome sequencing was performed on a unique collection of isogenic, clinical (21 strains) and laboratory (12 strains) derived strains...

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Bibliographic Details
Main Authors: Anton Y Peleg, Spiros Miyakis, Doyle V Ward, Ashlee M Earl, Aileen Rubio, David R Cameron, Satish Pillai, Robert C Moellering, George M Eliopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3253072?pdf=render