Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

Abstract Background Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In these conditions, disease progression is associated with epithelial damage and fragility, airway remodelling and sub-e...

Full description

Bibliographic Details
Main Authors: Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Respiratory Research
Subjects:
TGFβ1
Poly I:C
Remodelling
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12931-017-0565-2

Internet

http://link.springer.com/article/10.1186/s12931-017-0565-2

Similar Items