Resolving rates of mutation in the brain using single-neuron genomics

Resolving rates of mutation in the brain using single-neuron genomics

Whether somatic mutations contribute functional diversity to brain cells is a long-standing question. Single-neuron genomics enables direct measurement of somatic mutation rates in human brain and promises to answer this question. A recent study (Upton et al., 2015) reported high rates of somatic LI...

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Bibliographic Details
Main Authors: Gilad D Evrony, Eunjung Lee, Peter J Park, Christopher A Walsh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
single-cell genomics
somatic mutation
mosaicism
brain
retrotransposons
LINE-1
Online Access:https://elifesciences.org/articles/12966

Internet

https://elifesciences.org/articles/12966

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