Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function

Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function

Isocitrate dehydrogenase (IDH) is an enzyme required for the production of α-ketoglutarate from isocitrate. IDH3 generates the NADH used in the mitochondria for ATP production, and is a tetramer made up of two α, one β and one γ subunit. Loss-of-function and missense mutations in both IDH3A and IDH3...

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Bibliographic Details
Main Authors: Amy S. Findlay, Roderick N. Carter, Becky Starbuck, Lisa McKie, Klára Nováková, Peter S. Budd, Margaret A. Keighren, Joseph A. Marsh, Sally H. Cross, Michelle M. Simon, Paul K. Potter, Nicholas M. Morton, Ian J. Jackson
Format: Article
Language:English
Published: The Company of Biologists 2018-12-01
Series:Disease Models & Mechanisms
Subjects:
Krebs cycle
Mouse model
Retinitis pigmentosa
Online Access:http://dmm.biologists.org/content/11/12/dmm036426

Internet

http://dmm.biologists.org/content/11/12/dmm036426

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