Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely...

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Bibliographic Details
Main Authors: Paul E Chappell, El Kahina Meziane, Michael Harrison, Łukasz Magiera, Clemens Hermann, Laura Mears, Antoni G Wrobel, Charlotte Durant, Lise Lotte Nielsen, Søren Buus, Nicola Ternette, William Mwangi, Colin Butter, Venugopal Nair, Trudy Ahyee, Richard Duggleby, Alejandro Madrigal, Pietro Roversi, Susan M Lea, Jim Kaufman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-04-01
Series:eLife
Subjects:
HIV
Marek's disease
peptide repertoire
avian
MHC
Online Access:https://elifesciences.org/articles/05345

Internet

https://elifesciences.org/articles/05345

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