Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients

Galectin-8 belongs to a family of mammalian lectins that recognize glycoconjugates present on different cell surface components and modulate a variety of cellular processes. A role of Gal-8 in the immune system has been proposed based on its effects in immune cells, including T and B lymphocytes, as...

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Bibliographic Details
Main Authors: Lucas Vicuña, Evelyn Pardo, Cristóbal Curkovic, Remziye Doger, Claudia Oyanadel, Claudia Metz, Loreto Massardo, Alfonso González, Andrea Soza
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Biological Research
Subjects:
SLE
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300008&lng=en&tlng=en