Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes

Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes

Abstract Background Maternal malaria is a tropical scourge associated with poor pregnancy outcomes. Women become resistant to Plasmodium falciparum pregnancy malaria as they acquire antibodies to the variant surface antigen VAR2CSA, a leading vaccine candidate. Because malaria infection may increase...

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Bibliographic Details
Main Authors: Michal Fried, Jonathan D. Kurtis, Bruce Swihart, Robert Morrison, Sunthorn Pond-Tor, Amadou Barry, Youssoufa Sidibe, Sekouba Keita, Almahamoudou Mahamar, Naissem Andemel, Oumar Attaher, Adama B. Dembele, Kadidia B. Cisse, Bacary S. Diarra, Moussa B. Kanoute, David L. Narum, Alassane Dicko, Patrick E. Duffy
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Malaria Journal
Subjects:
Placental malaria
VAR2CSA
Birth weight
Pregnancy loss
Preterm delivery
Anaemia
Online Access:http://link.springer.com/article/10.1186/s12936-018-2258-9

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http://link.springer.com/article/10.1186/s12936-018-2258-9

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