Induction of antigen-specific Treg cells in treating autoimmune uveitis via bystander suppressive pathways without compromising anti-tumor immunity

Induction of antigen-specific Treg cells in treating autoimmune uveitis via bystander suppressive pathways without compromising anti-tumor immunity

ABSTRACT: Background: Induction of autoantigen-specific Treg cells that suppress tissue-specific autoimmunity without compromising beneficial immune responses is the holy-grail for immunotherapy to autoimmune diseases. Methods: In a model of experimental autoimmune uveitis (EAU) that mimics human u...

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Bibliographic Details
Main Authors: Zilin Chen, Tian Zhang, Hio Tong Kam, Dijie Qiao, Wenwen Jin, Yajie Zhong, Minyi Zhou, Hongyan Zhou, Wai Po Chong, Wanjun Chen, Jun Chen
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:EBioMedicine
Subjects:
Treg
autoantigen
immunotherapy
experimental autoimmune uveitis
tumor immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002899

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http://www.sciencedirect.com/science/article/pii/S2352396421002899

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