Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial

Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial

BackgroundInterleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise. We recently showed that an acute increase in IL-6 delayed gastric emptying rate and improved postprandial glycemia. Here we in...

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Main Authors: Louise Lang Lehrskov, Regitse Højgaard Christensen, Anne-Sophie Wedell-Neergaard, Grit Elster Legaard, Emma Dorph, Monica Korsager Larsen, Marie Henneberg, Natja Launbo, Sabrina Ravn Fagerlind, Sidsel Kofoed Seide, Stine Nymand, Maria Ball, Nicole Vinum, Camilla Dahl, Nicolai Jacob Wewer Albrechtsen, Jens Juul Holst, Mathias Ried-Larsen, Jaya Birgitte Rosenmeier, Rikke Krogh-Madsen, Kristian Karstoft, Bente Klarlund Pedersen, Helga Ellingsgaard
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physiology
Subjects:
interleukin-6
gastric emptying
exercise
tocilizumab
glucagon
GLP-1
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01249/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.01249/full

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