Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data

Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data

Abstract Background The concentrations of distinct types of RNA in cells result from a dynamic equilibrium between RNA synthesis and decay. Despite the critical importance of RNA decay rates, current approaches for measuring them are generally labor-intensive, limited in sensitivity, and/or disrupti...

Full description

Bibliographic Details
Main Authors: Amit Blumberg, Yixin Zhao, Yi-Fei Huang, Noah Dukler, Edward J. Rice, Alexandra G. Chivu, Katie Krumholz, Charles G. Danko, Adam Siepel
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Biology
Subjects:
RNA half-life
RNA splicing
Epigenomics
PRO-seq
Structural equation modeling
Online Access:https://doi.org/10.1186/s12915-021-00949-x

Internet

https://doi.org/10.1186/s12915-021-00949-x

Similar Items