Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington’s disease

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington’s disease

In Huntington’s disease (HD), genetic factors in addition to the HD CAG repeat mutation play a significant role in determining age at neurologic onset. Brain-derived neurotrophic factor (BDNF), a survival factor for striatal neurons, has been implicated as a target of regulation by huntingtin and is...

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Bibliographic Details
Main Authors: Shotaro Kishikawa, Jian-Liang Li, Tammy Gillis, Michael M. Hakky, Simon Warby, Michael Hayden, Marcy E. MacDonald, Richard H. Myers, James F. Gusella
Format: Article
Language:English
Published: Elsevier 2006-11-01
Series:Neurobiology of Disease
Subjects:
Huntington’s disease (HD)
Brain-derived neurotrophic factor (BDNF)
Age at onset
Genetic modifier
Functional polymorphism
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001732

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http://www.sciencedirect.com/science/article/pii/S0969996106001732

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