Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action

Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action

Fungal pathogens continue to pose challenges to humans and plants despite efforts to control them. Two coumarins, robustic acid and thonningine-C isolated from Millettia thonningii, show promising activity against the fungus Candida albicans with minimum fungicidal concentration of 1.0 and 0.5 mg/mL...

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Bibliographic Details
Main Authors: Daniel M. Ayine-Tora, Robert Kingsford-Adaboh, William A. Asomaning, Jerry J.E.K. Harrison, Felix C. Mills-Robertson, Yahaya Bukari, Patrick O. Sakyi, Sylvester Kaminta, Jóhannes Reynisson
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Molecules
Subjects:
natural products
Candida albicans
molecular modelling
CYP51
Sclorotium
isoflavone
Online Access:http://www.mdpi.com/1420-3049/21/10/1369

Internet

http://www.mdpi.com/1420-3049/21/10/1369

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