Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome

Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome

LIS1 is the main causative gene for lissencephaly, while MeCP2 is the main causative gene for Rett syndrome, both of which are neurodevelopmental diseases. Here we report nuclear functions for LIS1 and identify previously unrecognized physical and genetic interactions between the products of these t...

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Bibliographic Details
Main Authors: Liraz Keidar, Gabi Gerlitz, Aditya Kshirsagar, Michael Tsoory, Tsviya Olender, Xing Wang, Ying Yang, Yu-Sheng Chen, Yun-Gui Yang, Irina Voineagu, Orly Reiner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
lissencephaly
Rett syndrome
LIS1
MeCP2
genetic interactions
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00370/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00370/full

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