Expanding metabolic pathway for de novo biosynthesis of the chiral pharmaceutical intermediate l-pipecolic acid in Escherichia coli

Expanding metabolic pathway for de novo biosynthesis of the chiral pharmaceutical intermediate l-pipecolic acid in Escherichia coli

Abstract Background The six-carbon circular non-proteinogenic compound l-pipecolic acid is an important chiral drug intermediate with many applications in the pharmaceutical industry. In the present study, we developed a metabolically engineered strain of Escherichia coli for the overproduction of l...

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Bibliographic Details
Main Authors: Hanxiao Ying, Sha Tao, Jing Wang, Weichao Ma, Kequan Chen, Xin Wang, Pingkai Ouyang
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Microbial Cell Factories
Subjects:
Chiral intermediate biosynthesis
Lysine cyclodeaminase
l-Pipecolic acid
Metabolic engineering
Cofactor engineering
Online Access:http://link.springer.com/article/10.1186/s12934-017-0666-0

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http://link.springer.com/article/10.1186/s12934-017-0666-0

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