Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

Empagliflozin and metformin are widely used for the treatment of type 2 diabetes. These drugs showed marked anti-inflammatory effects in different animal models via enhancing AMPK activity. Yet, the protective anti-inflammatory effects of their combination against ulcerative colitis have not been pr...

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Bibliographic Details
Main Authors: Mahmoud E. Youssef, Eslam E. Abd El-Fattah, Amir M. Abdelhamid, Hanan Eissa, Eman El-Ahwany, Noha A. Amin, Helal F. Hetta, Mohamed H. Mahmoud, Gaber El-Saber Batiha, Naglaa Gobba, Ahmed Gaafar Ahmed Gaafar, Sameh Saber
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
empagliflozin
metformin
ulcerative colitis
dextran sulfate sodium
AMPK
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.719984/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.719984/full

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