The Relative Importance of the Small Intestine and the Liver in Phase II Metabolic Transformations and Elimination of <i>p</i>-Nitrophenol Administered in Different Doses in the Rat

The Relative Importance of the Small Intestine and the Liver in Phase II Metabolic Transformations and Elimination of <i>p</i>-Nitrophenol Administered in Different Doses in the Rat

Intestinal and hepatic function have been investigated in phase II metabolic reactions and elimination of <i>p</i>-nitrophenol (PNP) in the rat. A jejunal loop was cannulated and recirculated with isotonic solutions containing PNP in different concentrations (0, 20, 100, 500, 1000 µM). S...

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Bibliographic Details
Main Authors: Attila Almási, Pál Perjési, Emil Fischer
Format: Article
Language:English
Published: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2020-11-01
Series:Scientia Pharmaceutica
Subjects:
<i>p</i>-nitrophenol
conjugation reactions
drug metabolism
dose-dependent elimination
intestinal metabolism
Online Access:https://www.mdpi.com/2218-0532/88/4/51

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https://www.mdpi.com/2218-0532/88/4/51

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